Summer 2026

Deep Breath: Occupational Lung Diseases and Pharmacy Management

Fast Focus

Occupational lung diseases make up a small but significant portion of workers’ comp claims, and an uptick in wildfires across the U.S. has increased the frequency of these claims among firefighters. This influx of attention warrants an in-depth exploration of occupational lung diseases, other at-risk populations, and considerations for pharmacy management.

Occupational lung diseases make up a small portion of workers’ comp claims, but they can incur significant costs as these diseases are often present for life, developing over the course of years and progressing slowly, requiring life-long monitoring, treatment, and medication, leading to high costs and significant claim complexity.

While these types of claims have been present in workers’ comp for decades, in recent years, increased wildfire activity has brought greater attention to occupational lung diseases, particularly among firefighters.

According to NASA, climate change has amplified wildfire activity, with extreme wildfires becoming larger, more intense, and more frequent. Hotter weather, the earlier melting of snow, warmer nighttime temperatures, and a decrease in rainfall have led to fire seasons that are a month longer than ever before.1

Approximately 64,987 wildfires were reported in 2024 by the National Interagency Fire Center, a significant increase from 56,580 in 2023.2 The Palisades Wildfires alone resulted in 122 workers’ comp claims, 80% of which were for respiratory-related injuries.3

Expanding Presumption in the Future?

Many states have expanded cancer presumptions for firefighters, particularly lung cancer. However, there is significant diversity in which jurisdictions consider different occupational lung diseases compensable – both within firefighter populations and beyond. Regardless, legislatures across the country continue to introduce bills that could potentially expand various workers’ comp presumptions.

And while the conversation surrounding occupational lung diseases may have grown larger due to increased wildfire activity, it is important to understand how other industries see higher rates of lung diseases due to occupational exposure to various particles, fumes, vapors, and other exposures.

Cost and Claim Impacts of Occupational Lung Diseases

Occupational lung diseases – regardless of which occupation they originate from – can drive up costs in workers’ comp claims, as these conditions are typically chronic, can involve long-term medical treatment that potentially includes high-cost therapies, and often result in higher claim severity compared to acute injuries. While there’s limited data about the financial impact of lung disease specific to workers’ comp, the overall medical cost of all respiratory diseases annually in the U.S. is $170.8 billion.4

However, due to the diversity of lung diseases, the breakdown of costs varies. For instance, $11.9 billion is spent annually for COPD (chronic obstructive pulmonary disease) prescription drugs.5 Meanwhile, the CDC reports that medical expenditures for occupational asthma exceed $1 billion annually.6

The medications and therapies used to treat occupational lung diseases vary as well, requiring a deeper dive into the different types of diseases.

Types of Occupational Lung Conditions

There is an incredible range to what constitutes an occupational lung disease. However, they can be divided into three groups, each of which contains multiple subcategories:

Interstitial Lung Diseases

Interstitial lung diseases (ILDs) are a group of lung disorders that cause inflammation and scarring (also known as fibrosis) in the tissues surrounding the air sacs, impacting the ability to breathe and leading to shortness of breath and a dry cough.7-8 These conditions are typically irreversible and require lifelong management.

Common occupational causes include:9

Mineral dusts (silica, asbestos, beryllium, etc.)

Organic exposures (mold, animal proteins, hay, etc.)

Metal dusts and fumes

Why ILDs matter in workers’ comp:

Long latency periods complicate causation

Disease progression continues after exposure ends

High reliance on specialty medications

ILD Type
Example Impacted Occupations
Asbestosis10

Carpenters, boiler room workers, construction workers, shipyard workers, maintenance and insulation workers, vehicle brake mechanics, tile workers, shingles workers, textile workers

Hypersensitivity Pneumonitis10

Agricultural workers, animal-related workers, food processing workers, manufacturing workers

Silicosis10

Mining, tunneling, and quarry workers, construction workers, stonemasonry and stonewashing workers, ceramic and pottery workers

Chronic Beryllium Disease10

Workers in the electronics, aerospace, telecommunications, and nuclear industries

Metal Dust-Induced Granulomatosis10

Workers involved in aluminum plants, welding and smelting, automotive industries, milling and grinding, paint production, aircraft and aerospace industries, and the nuclear industry

Pulmonary Fibrosis11

Occupations with exposure to silica dust, asbestos fibers, hard metal dusts, mold, and bird and animal droppings

Pneumoconiosis9

Coal workers and textile workers

Obstructive Lung Diseases (OLDs)

These diseases narrow the airways, trapping air and making it difficult to exhale, leading to chronic shortness of breath, wheezing and coughing 9-10, 12-13 In workers’ comp, OLD claims are relatively uncommon but can become costly due to chronic symptom management, frequent exacerbations, and the need for ongoing medication therapy.

Common occupational contributors include:9-10, 12-13

Long‑term exposure to dusts (coal, silica, grain, textile fibers)

Chemical fumes and vapors

Diesel exhaust and welding fumes

Agricultural and industrial airborne irritants

Why OLDs matter in workers’ comp:

Conditions may develop gradually, complicating causation

Pre‑existing disease is often present and may be exacerbated by work exposure

Management frequently includes lifelong inhaler therapy and episodic acute care

Pharmacy costs accumulate over time rather than appearing as a single large expense

OLD Type
Example Impacted Occupations
Chronic Obstructive Pulmonary Disease (COPD)9-10

Primarily associated with those working in mining, agriculture, manufacturing, specifically textiles, rubber, and plastic

Occupational Asthma13

Adhesive handlers, users of plastic or epoxy resins, chemical manufacturers, spray painters, textile workers, insulation installers, plastics and foam workers, welders, metal workers, animal handlers, veterinarians, food production workers, hairdressers, seafood processors, forest workers, carpenters, cabinet makers, carpet makers, healthcare workers and pharmaceutical workers

Bronchiolitis Obliterans (also known as Popcorn Lung)14

Impacts those who work with flavoring chemicals used in food flavoring and production industries, including microwave popcorn, bakers mix, and flavored coffee industries

Bronchiectasis14

This condition often occurs with other lung conditions, due to damage to the walls of the airways. This damage can cause mucus to flare up, allowing for infections

Asthma: Occupational, Work-Related, or Work-Aggravated?

It is important to understand the difference between occupational asthma, work-related asthma, and work-aggravated asthma.

“Work-related asthma” can include pre-existing asthma that is exacerbated by workplace exposure to irritants; with these flare-ups of symptoms, removing an individual from the irritants can help reduce symptoms. However, “work-aggravated asthma” can refer to pre-existing asthma that is persistently worsened due to exposure to certain irritants.

“Occupational asthma” typically requires a period of repeated allergen exposure before the onset of symptoms. During this latent period the body becomes sensitive to the allergen(s) and immunological responses develop.10 However, irritant-induced occupational asthma can develop after exposures to high concentrations of airborne agents with corrosive or oxidative properties (e.g. strong acids and bases) and may develop after a single massive exposure to irritants, which usually occur in chemical accidents, fires or other hazardous events.10

At times, the terms “occupational asthma,” “work-related asthma,” and “work-aggravated asthma,” may incorrectly be used interchangeably, making it important to understand their differences, prevalence in the workforce, as well as applicable presumptions.

Lung Cancers

Lung cancer is one of the most severe occupational lung conditions and carries the highest potential for catastrophic claim costs. Symptoms often do not appear until the disease is advanced, leading to delayed diagnosis and intensive treatment once identified.

Although lung cancer claims are rare in workers’ compensation, they are among the most complex to manage due to long latency periods, high treatment costs, and evolving therapeutic approaches.

Occupations frequently impacted by lung cancer include:16-19

Welders, copper smelting, iron and steel founding

Uranium mining

Roofers, asphalt workers, painters, construction and demolition workers

Automobile parts manufacturers

Bartenders and servers

Chemists and printers

1 in 19 Americans will develop lung cancer in their lifetime20

54-75% of occupational cancers are lung cancer21

Why Lung Cancer Matters in Workers’ Comp

Long latency periods make exposure documentation and causation difficult

Claims often involve presumptions, particularly for firefighters

Treatment frequently includes specialty drugs, immunotherapy, and combination regimens

Costs extend beyond pharmacy to include radiation, surgery, and supportive care

The Link Between Lung Cancer and Mesothelioma

It is important to note the distinction between lung cancer and mesothelioma, because they arise from different tissues and therefore require different treatment approaches.

Mesothelioma is cancer of the mesothelium, the lining of tissue around the organs, usually the lining of the lungs. While this cancer is not formed within the lungs and is technically not a lung cancer, it is often grouped together with lung cancer. Mesothelioma is caused by exposure to asbestos. Symptoms include shortness of breath, pain in the chest, persistent cough, night sweats, swallowing problems, fatigue, fever, and weight loss without trying.22

Occupations frequently impacted by mesothelioma include:22

Construction workers
Navy veterans, shipbuilders, and shipyard workers
Industrial workers, power plant workers, and textile mill workers
Asbestosis miners

Considerations for the Pharmacy Management of Occupational Lung Diseases

Due to the sheer variety of chronic lung diseases, the medications used to treat lung diseases which are occupational in origin – if those conditions have effective drug therapies – are diverse. While there are non-pharmacological therapies for various lung diseases, medications help to slow down the progression of some diseases and/or to treat symptoms, flare-ups, and other conditions that can aggravate lung diseases.

While patient-specific factors can help determine which medications can best treat a particular occupational lung disease – the success of these treatments are determinable by exposure removal – there are larger considerations for these medication classes.

Long-Duration Therapy and Cumulative Cost Exposure

Because many occupational lung diseases are life-long conditions – with exceptions like occupational asthma, which can improve after exposure removal – patients may require long-term medications, often having to switch or combine medications over the course of a claim. This requires effective drug monitoring and can incur significant costs over time.

Common drugs used for the long-term treatment of lung diseases such as COPD, asthma, ILD, and pulmonary fibrosis can include:

Long-Acting Bronchodilators

These inhalers relax the muscles around the airways to relieve coughing and make breathing easier

Inhaled Corticosteroids

These drugs help reduce airway inflammation in the lungs to provide relief for various lung diseases

Combination Inhalers

These drugs combine multiple bronchodilators and/or inhaled corticosteroids

Leukotriene Modifiers

An alternative to corticosteroids, these drugs are used for the long-term management of obstructive lung diseases, helping to reduce inflammation

Antifibrotics

These drugs slow the formation of scar tissue, as excess scar tissue in the lungs makes breathing more difficult

Immunosuppressants

These drugs suppress an overactive immune system from further damaging lung tissue

Phosphodiesterase-4 (PDE4) inhibitors

These drugs block certain enzymes to reduce inflammatory activity

Episodic Escalation, Flare-Ups, and Secondary Concerns

At times, the symptoms of occupational lung diseases can worsen, flare up, or be exacerbated by other conditions. This can result in the need for additional medications.

For instance, a flare-up of symptoms could require the temporary use of short-acting bronchodilators or oral corticosteroids in addition to long-term medications, in order to provide more acute, short-term relief.

Occupational lung diseases can also be exacerbated by infections, a buildup of mucus, and gastroesophageal reflux diseases (GERD).15, 24-25 This can require the prescription of various antibiotics, mucus thinners, or GERD agents such as antacids, H2 blockers, or proton pump inhibitors.

Each of these medication classes not only incur additional costs, but they add additional elements of complexity within pharmacy management.

Complex Safety Profiles

The medications used to treat occupational lung diseases come with various safety considerations, especially as patients may be taking several of these drugs at a time. To promote safe and effective therapy, pharmacy management requires a deep understanding of these medications and their potential risks.

This can include but is not limited to:

Cardiovascular considerations for bronchodilators and leukotriene modifiers26-27

Gastrointestinal effects associated with antifibrotics, immunosuppressants, and leukotriene modifiers26-32

Liver concerns with antifibrotics and PDE4 inhibitors 28, 33

Hematological issues with immunosuppressants31-32

Mental health considerations for PDE4 inhibitors and leukotriene modifiers27,33

The heightened risk of developing or progressing diabetes, weight gain, cataracts, osteoporosis, or infection with high doses of corticosteroids34

Specialty/Oncology Considerations

In addition to possible surgery, radiation, and chemotherapy, there are medications that can help treat lung cancer patients. However, cancer therapies are constantly evolving, and the newer, more effective, and least toxic drugs tend to come with the highest price tags. Many of these newer drugs are becoming part of the standard of care.

This means that while cancer survival rates are higher than ever – cancer deaths have decreased by 33% over the last 30 years35 – the cost of cancer care continues to rise as new drugs enter the market.

Drug Adherence Considerations

Given the complexity and long-term nature of occupational lung diseases, drug adherence is a significant factor in providing optimal care, as treatment needs may evolve over time.

In workers’ compensation, these claims often demand specialized expertise, and appropriate treatment decisions often hinge on the clinical judgment and insights of the treating physician. However, additional healthcare professionals can play a supportive role. For example, connecting patients with a clinical pharmacist can support medication adherence and advise patients on managing side effects.

Additionally, when it comes to various inhaler-based medications, patient understanding of how to use these medications can impact effectiveness. As many as 70% to 80% of people with asthma are unable to use their inhaler devices correctly, making it important to evaluate if patients understand safe and effective techniques for using their inhalers.36

Case Study: Optimizing Maintenance Therapy in a Chronic Respiratory Disease Patient

Case Study:
Optimizing Maintenance Therapy in a Chronic Respiratory Disease Patient37
Patient:
56-year-old female; “Eileen K.”
Diagnoses:
Severe Asthma
History of Present Illness:
Patient presents with shortness of breath, wheezing, and coughing, despite reported use of maintenance inhalers. Ms. K works in a building that is being renovated and has had difficulty breathing due to the smoke from the renovation.
Current Maintenance Regimen:
• Symbicort® (budesonide and formoterol) – a combination inhaled corticosteroid (ICS) and long-acting beta-2 agonist (LABA) bronchodilator
• Spiriva® (tiotropium) – Long-acting muscarinic agonist (LAMA)
Assessment:
Current therapy involves multiple inhalers to achieve triple therapy coverage, contributing to treatment complexity, higher medication burden, and potential challenges with consistent daily use.
Adherence and Utilization Concerns:
Pharmacy fill history for Symbicort showed 3-4 month intervals for 30-day supplies, suggesting inconsistent adherence to maintenance therapy.
Clinical Recommendation and Rationale:
• Recommend transitioning from current maintenance therapy (Symbicort + Spiriva) to a single-inhaler triple therapy, such as Trelegy Ellipta (fluticasone/umeclidinium/vilanterol), to maintain ICS/LABA/LAMA coverage
• Trelegy Ellipta is a once daily, long-term maintenance inhaler combining three medicines: fluticasone furoate, an inhaled corticosteroid (ICS); umeclidinium, a long-acting muscarinic antagonist (LAMA); and vilanterol, a long-acting beta 2-adrenergic agonist (LABA) and is indicated for maintenance treatment of airflow obstruction in adults with chronic obstructive pulmonary disease (COPD) and the maintenance treatment of asthma in adults38
• Educate the patient on proper inhaler technique
• Continue to counsel the patient to identify and avoid asthma triggers, such as allergens
• Follow-up with the provider to evaluate symptom control
Therapy Option
Estimated Monthly Cost (AWP)
Estimated Annual Cost (AWP)
Symbicort® 160/4.5 mcg

$468.56

$5,622.72

Spiriva® 18 mcg

$614.44

$7,373.28

Estimated Total Monthly cost on current therapy: $1,083

Estimated Total Yearly cost on current therapy: $12,996

Trelegy Ellipta® 200 mcg

$357.08

$4,284.96

Estimated Monthly Savings: $725.92

Estimated Annualized Savings: $8,711

*AWP- Average Wholesale Price

References

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Since 2010, the semi-annual RxInformer clinical journal has been a trusted source of timely information and guidance for workers’ comp payers on how best to manage the care of injured worker claimants and plan for the challenges that lay ahead. The publication is an important part of Healthesystems’ proactive approach to advocating for quality care of injured workers while managing the costs associated with treatment.